Wenyu Song

A genome-wide Association study of the Count of Codeine prescriptions

Sci Rep. 2024 Oct 1;14(1):22780. doi: 10.1038/s41598-024-73925-4.ABSTRACTOpioid prescription records in existing electronic health record (EHR) databases are a potentially useful, high-fidelity data source for opioid use-related risk phenotyping in genetic analyses. Prescriptions for codeine derived

W Wenyu Song
David Merola

Calibrating Observational Health Record Data Against a Randomized Trial

JAMA Netw Open. 2024 Sep 3;7(9):e2436535. doi: 10.1001/jamanetworkopen.2024.36535.ABSTRACTIMPORTANCE: The conditions required for health record data sources to accurately assess treatment effectiveness remain unclear. Emulation of randomized clinical trials (RCTs) with health record data and subsequ

D David Merola
Piaopiao Li

Developing an automated algorithm for identification of children and adolescents with diabetes using electronic health records from the OneFlorida+ clinical research network

Diabetes Obes Metab. 2024 Sep 30. doi: 10.1111/dom.15987. Online ahead of print.ABSTRACTAIM: To develop an automated computable phenotype (CP) algorithm for identifying diabetes cases in children and adolescents using electronic health records (EHRs) from the UF Health System.MATERIALS AND METHODS:

P Piaopiao Li
Saeed Shurrab

Multimodal masked siamese network improves chest X-ray representation learning

Sci Rep. 2024 Sep 28;14(1):22516. doi: 10.1038/s41598-024-74043-x.ABSTRACTSelf-supervised learning methods for medical images primarily rely on the imaging modality during pretraining. Although such approaches deliver promising results, they do not take advantage of the associated patient or scan in

S Saeed Shurrab
Hamed Mohammadi

Tracing In-Hospital COVID-19 Outcomes: A Multistate Model Exploration (TRACE)

Life (Basel). 2024 Sep 21;14(9):1195. doi: 10.3390/life14091195.ABSTRACTThis study aims to develop and apply multistate models to estimate, forecast, and manage hospital length of stay during the COVID-19 epidemic without using any external packages. Data from Bellvitge University Hospital in Barcel

H Hamed Mohammadi
Fernando M Navarro Ros

Preclinical Evaluation of Electronic Health Records (EHRs) to Predict Poor Control of Chronic Respiratory Diseases in Primary Care: A Novel Approach to Focus Our Efforts

J Clin Med. 2024 Sep 21;13(18):5609. doi: 10.3390/jcm13185609.ABSTRACTBackground/Objectives: Managing chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) within the Spanish Sistema Nacional de Salud (SNS) presents significant challenges, particularly due to t

F Fernando M Navarro Ros
Anthony Spadaro

Parenteral Buprenorphine for Opioid Withdrawal

J Stud Alcohol Drugs. 2024 Sep 27. doi: 10.15288/jsad.24-00099. Online ahead of print.ABSTRACTOBJECTIVE: Buprenorphine is the standard of care for treatment of opioid withdrawal. However, when sublingual (SL) administration is not appropriate or practical, parenteral administration by the intravenou

A Anthony Spadaro
Swati Nagar

Disposition of Oral Nalbuphine and Its Metabolites in Healthy Subjects and Subjects with Hepatic Impairment: Preliminary Modeling Results Using a Continuous Intestinal Absorption Model with Enterohepatic Recirculation

Metabolites. 2024 Aug 27;14(9):471. doi: 10.3390/metabo14090471.ABSTRACTNalbuphine (NAL) is a mixed κ-agonist/μ-antagonist opioid with extensive first-pass metabolism. A phase 1 open-label study was conducted to characterize the pharmacokinetics (PKs) of NAL and select metabolites following single o

S Swati Nagar