JACC Adv. 2024 Oct 16;3(12):101297. doi: 10.1016/j.jacadv.2024.101297. eCollection 2024 Dec.
ABSTRACT
BACKGROUND: Familial hypercholesterolemia (FH) is a common genetic disorder that is strongly associated with premature cardiovascular disease. Effective diagnosis and appropriate treatment of FH can reduce cardiovascular disease risk; however, FH is underdiagnosed. Electronic health record (EHR)-based FH screening tools have been previously described to enhance the detection of FH.
OBJECTIVES: This scoping review explored the available literature on the performance and utility of existing EHR-based FH screening algorithms or tools.
METHODS: We searched PubMed, CINAHL, and Embase from inception to October 2023 for relevant literature on the performance, utility, and/or implementation of EHR-based screening algorithms for FH.
RESULTS: Of 14 screening algorithms and/or tools identified in the 27 studies included in this review, Familial Hypercholesterolemia Case Ascertainment Tool (1, 2, and ML), FIND FH algorithm, Mayo SEARCH, and TARB-Ex demonstrated the highest performance metrics for identifying patients with FH.
CONCLUSIONS: EHR-based screening tools hold great potential for improving population-level FH detection. Lack of established diagnostic criteria that can be applied across diverse populations and the lack of information about the performance, utility, and implementation of current EHR-based screening tools across diverse populations limit the current use of these tools.
PMID:39817076 | PMC:PMC11733818 | DOI:10.1016/j.jacadv.2024.101297